Monoterpenoids, neurotoxic effects

Toxicity and Neurotoxic Effects of Monoterpenoids In Insects and Earthworms... 

Neurotoxic Effects. Symptoms of acute poisoning of insects by monoterpenoids are similar to those effected by some neurotoxic compounds. Cockroaches and house flies both exhibited overt hyperactivity, loss of coordination, and tremors. In cat fleas, trembling and paralysis of legs were also noted, followed by convulsions and death (5). Our attempts to study the neurotoxic actions of d-limonene in American cockroach nerve preparations yielded somewhat erratic results, apparently due to difficulties of delivering and maintaining a specific concentration of this highly volatile and saline-insoluble chemical to the nerve. The non-invasive neuroassay for earthworms had been utilized successfully... 

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