Monoterpenes metabolism pulegone

Croteau R, Venkatachalam KV, Metabolism of monoterpenes Demonstration that (-l-)- t-isopulegone, not piperitenone, is the key intermediate in the conversion of (—)- isopiperitenone to (-l-)-pulegone in peppermint Mentha piperita), Arch Biochem Biophys 249 306—315, 1986. 

Nelson SD, McClanahan RH, Knebel N, Xhomassen D, Gordon WP, Doshi S, Xhe metabolism of (A)-(+)-pulegone, a toxic monoterpene, in Petrosky RJ, McCormick SP (eds.), Secondary-Metabolite Biosynthesis and Metabolism, Plenum Press, New York, USA, 1992. 

Engel, W., 2003. In vivo studies on the metabolism of the monoterpene pulegone in humans using the metab olism of ingestion correlated amounts (MICT approach Explanation for the toxicity differences between (S)-(-)- and (R)-(-t)-pulegone. 51 6589-6597. 

Plants especially from the Lamiaceae family can inhibit the growth of several weeds by releasing phytotoxic monoterpenes (a-pinene, P pinene, camphene, limonene, a-phellandrene, p-cymene, 1,8-cineole, borneol, pulegone, and camphor) (Angelini et al., 2003). The herbicide effect of 1,4-cineole and 1,8-cineole is also described by Dayan et al. (2012). Plants that are exposed to essential oils often metabolize them, and when citral was added geraniol, nerol and their acids appeared. When citronellal metabolization was tested, citronellol and citronellic acid were formed, and with pulegone (iso)-menthone, isopulegol and menthofuran were found (Dudai et al., 2000). 

Battalle, A. J. Burbott, and W. D. Loomis, Monoterpene Interconversions Metabolism of pulegone by a cell-free system from Mentha piperita, Phytochemistry 7 1159 (1968). 

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