Pharmacology monoterpene alkaloids

Chi YM, Nakamura M et al (2005) Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis. Biol Pharm Bull 28 1989-1991... 

During the past two decades a great number of papers have been published on the isolation, structure elucidation, synthesis and transformation, biogenesis, chemotaxonomy, and pharmacology of indole alkaloids. In this chapter we summarize the new results that appeared from 1968 to mid 1984 for the cory-nantheine-yohimbine group of monoterpene indole alkaloids with greater emphasis on their chemistry, excluding the related oxindoles and heteroyohimbines. 

Subsequent Reactions of Strictosidine Classification and Structural Types of Indole Alkaloids Formation of the Major Indole Alkaloid Types Summary of Pathways Leading to Major Types of Monoterpene-Derived Indole Alkaloids Chemosystematic and Phylogenetic Application Monoterpenoid Indole Alkaloids of Pharmacologic Significance Vincamine... 

The roots of R. serpentina contain 0.7 2.4% monoterpene indole alkaloids (Dewick, 2002). In addition to their main alkaloid reserpine, they also prodnce other pharmacologically active alkaloids, e.g., the antihypertensive ajmaUcine and the antiarrhythmic ajmaUne. AjmaUne blocks Na channels in the heart and thus prolongs inteaventricnlar condnction times. 

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