Monocyclic aromatic compounds

Both the older tricyclic antidepressants and the more recent drugs related to fluoxetine owe their efficacy to interaction with receptors for the neurotransmitters epinephrine, serotonin, and dopamine. The 

There is some evidence that points to an association between Alzheimer s disease and a defict in hrain acetylcholine levels. Considerable attention has thus focused on cholinesterase inhibitors as potential drugs for treating the affliction. The preparation of a relatively simple inhibitor is prepared by acylation of the benzylamine (197) with chloroformamide (198). The resulting urethane is then resolved to afford rivastigmine (199).  

Lednicer, The Organic Chemistry of Drug Synthesis, Vol. 5, John Wiley Sons, Inc., NY, 1995, p. 33. 

Amstuz, M. Marzi, M. Boelsterli, M. Walsinshaw, Helv. Chim. Acta 73, 739 (1990). 

React FeClj greenish black, on dilution olive 

Deriv Atranoloxime, brownish leaflets, mp 188-190 °C (dec.), from atranol with hydroxyl-amine 

6-Dihydroxy-2-methoxy-3-methylacetophenone (4,6-Dihydroxy-2-methoxy-3-methylacetophenon) 

React NaOCl red-violet, FeClj (EtOH) violet UV (MeOH) 274 nm (3.21) 

Deriv Diacetyldivarinol, mp 12-15 °C, from divarinol with ACjO-HjSO  

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Monocyclic Aromatic Compounds. Except for six retained names, all monocyclic substituted aromatic hydrocarbons are named systematically as derivatives of benzene. Moreover, if the substituent introduced into a compound with a retained trivial name is identical with one already present in that compound, the compound is named as a derivative of benzene. These names are retained ... 

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