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Monoclonal antibodies historical development

The development of monoclonal antibodies (mAbs) has revolutionized cancer treatment, and several mAbs are today approved for clinical use. Treatment resistance is often a problem in mAbs-treatment where multiple treatment series are necessary [100]. Dmg response can be increased by binding mAbs to cytotoxic compounds, such as protein toxins, forming immunotoxins (ITs) [101]. The historical problems with first and second generation ITs are largely solved by the use of recombinant DNA technology where chimeric proteins consisting of the Fv-ffagment of an antibody and... [Pg.275]

Nissim, A. and Chernajovsky, Y. (2008) Historical development of monoclonal antibody therapeutics. Handh. Exp. Pharmacol, 181, 3-18. [Pg.152]

See other pages where Monoclonal antibodies historical development is mentioned: [Pg.40]    [Pg.53]    [Pg.370]    [Pg.248]    [Pg.247]   
See also in sourсe #XX -- [ Pg.2 ]



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Historical development

Monoclonal antibodies development

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