Monensin Monoclonal antibodies

Immunotoxins composed of ricin A chain coupled to a cell-specific monoclonal antibody have continued to show promise as a new class of antitumor agents. Gnt tin and Raso investigated the use of the carboxylic ionophor monensin formulated in an O/W emulsion for the in vitro and in vivo potentiation of immu-notoxin.s. Monensin in this pharmacologically available form significantly improved the in vivo efficacy of both anti-human transferrin receptor immunotoxin and anticarcinoembryonic antigen immunotoxin when used as regional therapy. 

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