Monatin 4-hydroxy-4- glutamic acid

Monatin, 4-hydroxy-4-(indoT3-ylmethyl) glutamic acid, a high-intensity sweet, natural compound. Monatin was isolated from the roots of Schlerochiton ilicifolius, a spinyleaved hardwood shrub growing in South Africa. The synthesis of the four... 

Monatin [(25,45)-4-hydroxy-4-(indol-3-ylmethyl)-L-glutamic acid],... 

The 4-hydroxy-4-substituted glutamic acid moiety is the common substructure (stmcture 60) of several unusual, naturally occurring, biologically important amino acids such as monatin (61) [31] (high intensity sweetener), lyco-perdic acid (62) [32], and dysiherbaine (63) [33] (agonist of... 

In 1992, monatin [(25,45)-61], a 4-hydroxy,4-substituted glutamic acid, was isolated from the bark of the roots of Schlerochiton ilicifolius and reported to be 1000 to 1400 times sweeter than sucrose [31]. However, the natural supply of (25, 45)-61 from dried bark was insufficient for further... 

---