Molinate biotransformation

Figure 1 shows the rapid disappearance of molinate in water containing carp. The data indicate that the fish are largely responsible for molinate biotransformation and/or biodegradation. 

Molinate is well absorbed by the oral route. It is widely distributed with highest concentrations remaining in the circulation. There is no evidence for accumulation of molinate. It is nearly completely excreted within 48 h, primarily via the urine. The primary biotransformation pathway for molinate in rats is S-oxidation to sulfoxide, followed by hydrolysis (hexamethyleneimine) or conjugation (mercaptu-rate). In humans, ring hydroxylation is the primary route followed by glucuronidation. 

Tjeerdema, R.S. and D.G. Crosby. The biotransformation of molinate (Ordram) in the striped bass (Morone saxatilis). Aquat. Toxicol. 9 305-317, 1987. 

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