Molecular shape dipole moments affected

One molecular probe, which, in theory, has the specificity and low frequency transitional resolution desired is infrared (IR) spectroscopy. Although this technique has been used to observe polymer transitions (21-42), it has not been used as often or with the success of NMR and ESR. An IR absorption s intensity, band shape, and frequency may change with temperature. There are two extremes of interpretation of the spectroscopy results. Either thermal expansion affects the inherent nature of the dipole moment change, or the concentration of the absorbing species changes with temperature. These two effects can occur simultaneously. This often precludes a straightforward analysis. 

Figure 1 Depiction of the relationship between molecular structure and therapeutic effect of a medicine. Underlying all the other properties a compound can exhibit arc its 3D disposition of atomic nuclei and the electronic distribution around the nuclei. These inanimate particles of physics determine the chemistry the compound can undergo (reactivity) and its physical properties (density, index of refraction, dipole moment, etc.). The properties, in turn, determine how that molecule will interact with other molecules. The interactions determine solubility, lipophilicity, association, and stability, which affect how well a compound, if administered to a patient, will be transported to its site of action. These interactions will also determine how well the compound will attach to the receptor by first being recognized as complementary to the receptor structure in shape and electronic structure (acidic, basic, and hydrogen bonding groups). The affinity between the compound and the receptor will determine how well a biochemical or conformational change in the receptor will be induced. The latter change must then lead to a cascade of biochemical events that will eventually be observable in the patient in terms of therapeutic response to the drug...

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