Molecular recognition, high level

Many questions still remain with respect to both the biosynthesis and the mode of action of lantibiotics. Whereas the targets of the nisin, mersacidin, and cinnamycin groups are now known, the mechanism of action of many other lantibiotics (e.g., lacticin 481, Pep5, and sublancin) is still unclear. Similarly, the biosynthetic pathways still hold many unresolved questions, which include the molecular recognition that allows the synthetases their high level of substrate promiscuity and at the same time provides exquisite control of the regioselectivity of cyclization. 

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