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Molecular isoform

AMP-activated Protein Kinase. Table 1 Information about subunit isoforms of AMP-activated protein kinase. Data refer to the full-length forms of the human isoforms. The y2 and y3 isoforms also exist as splice variants that are N-terminal truncations, with lower molecular mass and number of amino acids (38 kDa and 328 amino acids for the short form of y2, 52 kDa and 464 amino acids for the short form of y3). Other splice variants may also exist... [Pg.70]

The newest molecular addition to Cl- channels are bestrophins [5]. There are four different bestrophin isoforms in humans. Mutations in Bestl cause Best macular dystrophy, hence their name. All four isoforms induce chloride currents when expressed heterologously. Although they show a dependence on intracellular calcium, their biophysical properties differ from Ca-activated chloride currents typically observed in native cells. Mutagenesis experiments changed the activation of currents and induced slight changes in ion selectivity, lending support to the hypothesis that bestrophins themselves are Cl- channels. [Pg.373]

G-actin (globular actin) has a molecular weight of about 42 kDa. In higher vertebrates, six isoforms of G-actin, which contain 374/375 residues, are expressed in a cell-specific manner. They are present in striated muscle cells (skeletal and cardiac isoforms), smooth muscle cells (vascular and visceral isoforms) and in non-muscle cells (two isoforms). [Pg.515]

Na+/Ca2+ Exchangers. Figure 4 Molecular properties of drugs interacting with NCX. Scheme summarizing the potency, the mode of selectivity, the molecular site of action and the isoform specificity of drugs interfering with NCX activity. [Pg.806]

All NOS isoforms utilize L-arginine as the substrate, and molecular oxygen and reduced nicotinamide adenine dinucleotide phosphate (NADPH) as cosubstrates. Flavin adenine dinucleotide (FMN), flavin mononucleotide (FAD), and (6R)-5,6,7,8-tetrahydro-L-biopterin (BH4) are cofactors of the enzyme. All NOS isoforms contain heme and bind calmodulin. In nNOS and eNOS,... [Pg.862]

I topoisomerase of mammals is a 100 kD monomeric protein whose activity is ATP-independent. This enzyme binds to double-stranded DNA and cleaves one of the DNA strands of the duplex, simultaneously forming an enzyme-DNA covalent bond between a tyrosine residue and the 3 -phosphate of the cleaved DNA. The type II topoisomerases are dimeric enzymes, which are ATP-dependant. Two isoforms of topoisomerase II exist, topoisomerase a and (3, with apparent molecular weights of 170 and 180 kD. Topoisomerase... [Pg.1212]

The principal molecular constituent of thin filaments is actin. Actin has been highly conserved during the course of evolution and is present in all eukaryotes, including single-celled organisms such as yeasts. Actin was first extracted and purified from skeletal muscle, where it forms the thin filaments of sarcomeres. It also is the main contractile protein of smooth muscle. Refined techniques for the detection of small amounts of actin (e.g., immunofluorescence microscopy, gel electrophoresis, and EM cytochemistry) subsequently confirmed the presence of actin in a great variety of nonmuscle cells. Muscle and nonmuscle actins are encoded by different genes and are isoforms. [Pg.21]

Contrary to AE from orange peels described by Williamson (2) this AE has a higher molecular mass and pi > 9. AE isolated from mung bean, however, has. similar MW and pi in agreement with the present findings (1). These differences could indicate the presence of several AE isoformes in different varieties of orange fruits. [Pg.726]

There are at least five distinct isoforms of plasma membrane Ca -ATPases in mammalian tissues that differ in distribution and C-terminal sequences [34]. The molecular weight of these enzymes is in the range of 127 300-134683 (Table I) and they all contain calmodulin-binding domains [3], in contrast to the much smaller ( 110kDa) SERCA enzymes that are calmodulin independent. [Pg.59]

S. Santi, A. de Marco, G. Locci, S. Cesco, R. Pinton, and Z. Varanini. Possible involvement of root plasma membrane H -ATPa.se isoforms in the induction of nitrate tran.sport. Proc. 6th hit. Symp. Genetics and Molecular Biology of Plant Nutrition. Elsinore, Denmark, 1998, Mbl. [Pg.16]

The most X-ray intensive screening method was described by Card et al. [8] on the design of phosphodiesterase (PDE) inhibitors (Figure 1.7). The authors initially biochemically screened a 20,000 member library of small molecular weight (120-350 MW) core scaffold compounds against 5-PDE isoforms at 200 pM. Multiple isoforms of PDE were used in order to eliminate the number of false positives obtained from the screen. There were 316... [Pg.13]


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See also in sourсe #XX -- [ Pg.394 ]




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Isoform

Isoforms

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