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Modified Yamaguchi macrolactonization

Leighton s synthetic strategy is shown in Scheme 43. Side chain 200 was introduced by the Still-modified (Z)-selective Honer-Emmons reaction forming the C2 -C3 double bond. Macrolactonization leading to 201 was carried out by using the Yamaguchi procedure, and C17 asymmetric carbon was constructed by alkenylzinc addition to an aldehyde in 202. The 2,6-trans-tetrahyderopyran was synthesized by the Hosomi-Sakurai reaction to a lactol. [Pg.177]

See other pages where Modified Yamaguchi macrolactonization is mentioned: [Pg.227]    [Pg.449]    [Pg.501]    [Pg.179]    [Pg.227]    [Pg.449]    [Pg.501]    [Pg.179]    [Pg.546]    [Pg.69]    [Pg.83]    [Pg.309]    [Pg.419]   
See also in sourсe #XX -- [ Pg.501 ]



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