Models for Drug-Delivery Systems

W + L indicates the two-phase with excess water, L the microemulsion, and L -I- O the two-phase with excess oil. The figure is adapted from and data taken from ref [121]. 

C Es-water-decane system, where part of the lidocaine. The figures adapted from and data 

Self-diffusion NMR studies [121] confirms that the microemulsion systems initially consist of discrete aggregates that at higher temperatures change into bicon-tinuous microemulsions. The temperature increase needed to change the system into a bicontinuous microemulsion also changes with the amount of added 

82 I 3 Nonionic Microemulsions Dependence of Oil Chain Length and Active Component (Lidocaine) 300 

Some of the difference between the systems can be explained by a numerically smaller (negative) value of tc the longer the oil. 

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