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Modeling hydroxylation, liver cytochrome

More recently, an indirect method of electrochemical detoxification of organisms has been put into practice. It is based on a model of the detoxifying function of the liver. A normal liver produces cytochrome P450, which assures the hydroxylation... [Pg.411]

Arylhydrocarbon Hydroxylase. Benzo(a)pyrene (BaP) is considered an ideal model compound for monitoring arylhydrocarbon hydroxylase (AAH) MFO levels in rats. Its metabolism has been widely investigated in both rat liver and extrahepatic tissues (40-41,61 -70). Arylhydrocarbon hydroxylase has been compared to biphenyl hydroxylase in the intestines of rats (25,28). Intestinal AAH has been shown to be induced up to 30-fold with cytochrome P-448-type inducers, while being insensitive to P-450-type induction. Therefore, we have used intestinal AAH in conjunction with biphenyl hydroxylation, to evaluate the effects of dietary fibers on intestinal metabolism. [Pg.287]

See other pages where Modeling hydroxylation, liver cytochrome is mentioned: [Pg.127]    [Pg.325]    [Pg.217]    [Pg.143]    [Pg.202]    [Pg.260]    [Pg.350]    [Pg.236]    [Pg.260]    [Pg.2142]    [Pg.301]    [Pg.23]    [Pg.98]   


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