Model stage-gate

A time-and-motion modeling mind-set can easily blinker analysis of how best to improve the value created by research. Truly useful simulations of drug discovery must go beyond simplistic assumptions about yields at stage gates and address the causes of failure, starting to quantify the common concept of pipeline quality. ... 

Fig. 3. The ABB Gate Model. Based on Cooper s stage-gate model, it has seven decision points and one additional checkpoint (G7) to consider the achievements of the projects and collect experience useful for process improvement (reproduced from [14]).

The stage-gate model therefore supports traditional engineering practices and in turn may hamper other approaches, such as the UX designer s more agile approach. 

Membrane-casting Techniques. Uhtil recently, PVC membranes have been exclusively formed by solvent casting techniques but which are not well-suited to the fabrication of ISFET devices. Membrane components in tetrahydrofuran are difficult to manipulate on a micro scale and are prone to absorb atmospheric moisture, thus weakening the adhesion at the sensor-ISFET interface. Che innovation which dispenses with the tetrahydrofuran casting stage is based on an in situ photolysis of the model calciun sensor cocktail admixed with monobutyl methacrylate + benzoyl peroxide + benzoin methyl ether at 340 nm (3). Hie resultant matrix adhered well to the ISFET gate and its potentiate trie response compared favourably with the analogous P and P2-MPMA ISE (Table II). 

The gate corresponds to Z/L = 0.0 in tfie plot. Minimal conversion has occurred (plot not shown) thus these profiles are almost entirely due to conduction and not heat of reaction. Only mild axial variation of temperature is evident here, and even less would occur with more moderate molding temperatures. Under such circumstances, a one rather than two dimensional solution of the curing stage should suffice, simplifying the modeling procedure. 

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