Model building loop conformations

We used several methods were used to model antibody CDRs that can be divided into two categories (1) a knowledge-based approach that uses CDRs from known crystal structures of antibodies and (2) an ab-initio approach that builds CDR loops. All of these approaches must fulfill one criterion to identify the conformation that is best adapted to the framework of a current model. Unfortunately, none of the current methods has an... 

---