Modafinil Clomipramine

CLOMIPRAMINE MODAFINIL Variable effect on clomipramine CYP2C19 provides an ancillary pathway for the metabolism of clomipramine. Modafinil inhibits CYP2C19 reversibly at pharmacologically relevant concentrations. Modafinil also induces CYP1A2 Watch for both poor response and early features of toxicity of clomipramine... 

Wong YN, Gorman S, Simcoe D, McCormick GC, Grebow P. A double-blind placebo-control-led crossover study to investigate the kinetics and acute tolerability of modafinil and clomipramine alone and in combination in healthy male volunteers. Association of Professional Sleep Societies meeting, San Francisco, June 1997, Abstract 117. 

Grozir er M, Hartter, Hiemke C, Griese E-U, Roschke J. Interacticm of modafinil and clomipramine as comedication in a narcoleptic patient. Clin Neuropharmacol SOZ) 21,127-9. 

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