MLOGP method

One of the first but yet successful and weU known method, MLOGP, was developed by Moriguchi et al. [64]. MLOGP uses the sum of Hpophilic (carbons and halogens) and hydrophilic atoms (nitrogens and oxygens) as two basic descriptors. These two descriptors were able to explain 73% of the variance in the experimental log P values for 1230 compounds. The use of 11 correction factors covered 91% of the variance. Due to the simplicity of implementation, the MLOGP method was widely used as a calculation and reference approach for many years. 

Methods that produced results not significantly different from the method with the minimal MAE received rank 1, i.e. all methods with rank 1 had a similar best performance. After determination of this group, the remaining methods with results significantly better than those of MLOGP or AAM received rank 11 and 111, respectively. Methods that had an MAE non-significantly different from (or even worse than) AAM received rank IV. 

MlogP is one of the estimation methods of cLogP proposed by Moriguchi I. Moriguchi,... 

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