Mixing process normalized transfer function

The normalized RVD that describes the mixing in the process at steady state is modeled using a transfer function to obtain a master curve ( (v)). The master curve thus obtained is used to predict the dynamic mixing effects that occur as a response to a step input of the filler. The compositional gradient in the extrudate, which is a direct indication of the dynamic mixing effects, is predicted by convolution as,... 

Wisniewski [52] has extensively reviewed the equipment for large-scale HPLC. The old question of low-pressure or high-pressure mixing is now outdated. Due to advances in electronic and process control instruments, the reliable blending of solutions should not be a problem anymore. The mixer has to be characterized when scale-up is considered or when a purification method is transferred to another separation unit. We have described a simple function to characterize a mixer [53]. The system is characterized by a simple blending of two buffers—a salt buffer and the normal running buffer. When salt is used, a conductivity monitor is necessary. The column is disconnected from the system... 

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