Mixed function oxidases warfarin

Cytochrome P450 2C9 is a mixed-function oxidase localized in the endoplasmic reticulum which is responsible for the biotransformation of several nonsteroidal anti-inflammatory diugs, S-warfarin, several sulfonylurea antidiabetics and other diugs. 

Warfarin has hccn drlcrmiiicd from plasma 3f>7). Siinlics of iis metabolic fate due to the action of hepatic mixed function oxidases have profited from the use of reversed-phase columns for the determination of metabolites (368). Related studies on warfarin resistance have utilized vitamin Kt 2,3-epoxide to examine the rate of its reduction in rats to form X ilamin h the rraxMion was follitwcil x liromalxtitrapliii allv... 

M.G. MacDonald, M.J. Fasco, and L.S. Kainsky, Development of hepatic mixed function oxidase system and its metabolism warfarin in the perinatal rat. Dev. Pharmacol. Ther. 3 1, 1981. 

Correct choice = A. Rifampin induces the hepatic mixed function oxidases that metabolize warfarin. Platelet inhibitors, such as aspirin, increase the anticoagulant effect of warfarin. Phenylbutazone can transiently increase the level of free warfarin by displacing it from the plasma albumin binding site. Cimetidine inhibits warfarin metabolism and causes potentiation of the anticoagulant. Disulfiram inhibits warfarin metabolism. 

Interactions Chloramphenicol is able to inhibit some of the hepatic mixed function oxidases and thus can block the metabolism of such drugs as warfarin, phenytoin, tolbutamide and chlorpropamide, thus elevating their concentrations and potentiating their effects. 

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See also in sourсe #XX -- [ , ]

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