Mixed alkylthiol SAM

Self-assembly of one- or two-component alkylthiol SAMs provides a convenient tool for tailoring, at a molecular level, the chemical reactivity of a gold surface by choosing and modulating the nature and amount of surface-bound chemically reactive groups (e.g., -OH, -COOH, or -NH2) in the monolayer. Particularly, mixed alkylthiol SAMs prepared by coadsorption of alkylthiols... 

Scheme 4. Idealized sketches of gold surfaces for DNA hybridization sensors prepared by (a) chemisorption of thiolated ssDNA capture probes followed by chemisorption of a dilutor alkylthiol [168] and by (b) chemisorption of a mixed alkylthiol SAM followed by covalent attachment of an amino-terminated ssDNA capture probe (surface-bound carboxylic groups are activated by reaction with 0-(N-auccimrmdyl)-N,N,N, N -tetramethyluronium tetrafluoroborate in acetonitrile in the presence of N, A-diisopropylethylamine, [172]).

Scheme 14. Electrochemically-induced release of biotin from a gold electrode surface modified with a protein-resistant mixed alkylthiol SAM (biotinyl derivative attached to the alkylthiol SAM via a paraquinone moiety) [267],...

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