Mitotane Warfarin

MITOTANE ANTICOAGULANTS-WARFARIN Possible 1 anticoagulant effect Induction of metabolism of warfarin Monitor INR closely... [Pg.326]

ANTICOAGULANTS-ORAL AZATHIOPRINE, MERCAPTOPURINE, MITOTANE Possible i anticoagulant effect induction of metaboiism of warfarin Monitor iNR cioseiy... [Pg.469]

A number of case reports describe an increase in the effects of warfarin, accompanied by bleeding in some cases, caused by an-tineoplastic regimens containing carboplatin, chlormethine, cyclophosphamide, doxorubicin, etoposide, gefitinib, gemcitabine, ifosfamide with mesna, methotrexate, procarbazine, trastuzum-ab, vincristine or vindesine. A decrease in the effects of warfarin has been seen with azathioprine, cyclophosphamide, mercaptop-urine and mitotane, a decrease in the effects of acenocoumarol has been seen with mercaptopurine, and a decrease in the effects of phenprocoumon have l n seen with azathioprine. [Pg.382]

The anticoagulant effects of warfarin were progressively reduced in a woman taking mitotane. Later this effect began to reverse. [Pg.382]

Cuddy PG, Loftus LS. Influence of mitotane on the hypoprothrombinemic effect of warfarin, South Med J( 9S6) 79, 387-8,... [Pg.383]

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