Mitosane Mitosene

Functionalization of mitosenes has been studied thoroughly <85LA1413, 85LA1422,88LA381,89LA239, 90MI801-01 >. The Dotz reaction (84AG(E)587> offers a simple and versatile route to mitosanes. 

There are two groups of compounds belonging either to mitosenes (31) or mitosanes (32). Mitomycin A (33), mitomycin B (34) (76MI1), mitomycin C... 

In this review, the trivial names mitosane and mitosene [14] (Fig. 1) will be used to describe various mitomycin structures. For example, mitomycin C is 7-amino-9a-methoxymitosane. It should be noted that the numbering of a mitosane differs from the systematic numbering used in Chemical Abstracts for azirino[2, 3 3,4]pyrrolo[l,2-a]indoles, wherein the aziridine nitrogen is the starting point. 

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