Mitochondrial encephalopathy MELAS

The condition known as fatal infantile mitochondrial myopathy and renal dysfunction involves severe diminution or absence of most oxidoreductases of the respiratory chain. MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke) is an inherited condition due to NADHiubiquinone oxidoreductase (complex I) or cytochrome oxidase deficiency. It is caused by a muta-... 

The clinical symptoms of mitochondrial diseases are highly varied and include seizures, vomiting, deafness, dementia, stroke-like episodes, and short stature. Although there are many types of mitochondrial disorders, four of the most common types are as follows Kearns-Sayre syndrome, Leber s hereditary optic atrophy, MELAS (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes) and MERRE (myoclonic epilepsy with ragged red fibres). 

MELAS syndrome (mitochondrial encephalopathy lactic acidosis with stroke-like episodes)... 

MELAS (mitochondrial encephalopathy, lactic acidosis, and strokelike episodes)... 

Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS)... 

Al. Abe, K., Fujimura, H., Nishikawa, Y., Yorifuji, S., Mezaki, T., Hirono, N., Nishitani, N., and Kameyama, M., Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Acta Neurol. Scand. 83, 356-359 (1991). 

Mitochondrial cytopathy may present with stroke-like episodes often complicated by epilepsy and encephalopathy, a particular example of which is MELAS. Scanning with CT may show hypodensities, particularly in the occipital regions, and calcification of the... 

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes) 521, 525... 

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