Mitochondrial encephalomyopathies, with episodes

MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) resuits from a point mutation in the mitochondriai tRNA gene. 

L12. Liou, C. W., Huang, C. C., Lin, T. K., Tsai, J. L., and Wei, Y. H., Correction of pancreatic /3-cell dysfunction with coenzyme Qio in a patient with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome and diabetes mellitus. Eur. Neurol. 43, 54-55 (2000). 

Figure 8-4. The effect of the MELAS mutation on mitochondrial function is to interfere with function of respiratory Complex I or I and IV, leading to increased levels of NADH and thus also of lactate. CoQ, coenzyme Q MELAS, mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes RC, respiratory complex.

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