Mitochondria as Vascular O2 Sensors

The mitochondrial ETC consists of four huge, multieomponent complexes whose function is to transfer electrons from reducing equivalents such as NADH and FADH2, which are produced during glycolysis and the Krebs eyele (Fig. 1). Complex I of the ETC is an NADH dehydrogenase (Fig. 7). Here, NADH is redueed to NAD as it transfers its two electrons to ubiquinone, whieh is oxidized to ubiquinol. Rotenone is a specific inhibitor of complex I. Complex II is a flavoprotein 

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O2-sensitive K+ current is suppressed, much as occurs in PASMC with administration of reduced glutathione (Fig. 1 lb) (43). 

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