Misoprostol drug administration

Davies et al (1994) induced small intestinal permeability by anti-inflammatory drugs in rats. After oral administration of 51Cr-EDTA urinary excretion was increased by non-steroidal anti-inflammatory drugs. Misoprostol and sulfasalazin significantly reduced the effect of in-dome thacin. 

Misoprostol is rapidly absorbed after oral administration and then is rapidly and extensively de-esterified to form misoprostol acid, the principal and active metabolite of the drug. Some of this conversion may occur in the parietal cells. A single dose inhibits acid production within 30 minutes the therapeutic effect peaks at 60-90 minutes and lasts for up to 3 hours. Food and antacids decrease the rate of misoprostol absorption, resulting in delayed and decreased peak plasma concentrations of the active metabolite. The free acid is excreted mainly in the urine, with an elimination tj of about 20-40 minutes. 

Misoprostol—Take this drug four times a day widi meals and at bedtime Continue to take die NSAID during this drug ther iy. Take die drug widi meals to decrease the severity of diarrhea. The administration of antacids before or after misoprostol may decrease the pain. M nesium-containing antacids are avoided because of the risk of increasing die diarrhea. 

---