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Mismatch crystallographic study

The crystal structure of a very short patch repair (Vsr) endonuclease complex with DNA containing a TG mismatch shows novel interactions of intercalated aromatic side chains which recognise the mismatch site. The enzyme also distorts the DNA backbone, and many protein side chain interactions stabilise the complex. Crystallographic studies of duplexes containing the mutagenic... [Pg.267]

Crystallographic study of mismatches have concentrated on sequences known to crystallise into which the mispairs were engineered. A common framework has been the B-DNA Drew-Dickerson dodecamer duplex, d(CGCGAATTCGCG) (19). Other templates have been A-form DNA octamers and Z-form hexamers (20). In each case a duplex containing two mispairs has been formed. This approach maximises the chances of getting well ordered single crystals and means that there is a native Watson-Crick structure for comparative purposes. [Pg.80]

See other pages where Mismatch crystallographic study is mentioned: [Pg.215]    [Pg.263]    [Pg.509]    [Pg.511]    [Pg.1172]    [Pg.79]    [Pg.80]    [Pg.82]    [Pg.1165]    [Pg.160]    [Pg.37]    [Pg.247]    [Pg.1165]    [Pg.114]    [Pg.710]    [Pg.436]    [Pg.624]    [Pg.363]    [Pg.573]    [Pg.250]    [Pg.124]    [Pg.89]    [Pg.317]   
See also in sourсe #XX -- [ Pg.80 ]



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