Miscellaneous Barbier Reactions

Davies and Kipping 1911. Davies and Kipping (see also Sect. 1.4) were the earliest protagonists of the one-step Barbier reaction at a time when the euphoria over the use of Grignard s reagent seemed to have blinded chemists to other synthetic possibilities. 

In their early publications on the synthesis of organosilicon derivatives. Kipping and coworkers reacted benzyl chloride with magnesium in the presence of silicon chlorides [93]  

The success of this one-step procedure inspired Kipping and Davies to extend this type of reaction [50] to prepare 

They obtained good results with their one-step procedure (see Table 2.14) and came to the conclusion that 

Oddo and Del Rosso 1911. It was during that same period that research started on the composition and structure of Grignard compounds in solution. In 1906-7, Chelinzeff [94] investigated the role of the solvent by measurement of the heats of solvation for Grignard reagents. 

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Barbier-type reactions, 9, 433 in catalyzed C-C bond formation, 9, 438 in C-C bond formations, 9, 435 in C-heteroatom bond formations, 9, 440 with copper catalysts, 9, 442 non-catalyzed reactions, 9, 443 miscellaneous reactions, 9, 444 in oxidations, 9, 443 in reduction reactions, 9, 444 Bismuth(V) compounds... 

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