Minimizing metabolic activation, drug discovery

Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery... 

Minimizing Metabolic Activation in Drug Discovery Future Directions. 536... 

Although a major rationale for minimizing metabolic activation during drug discovery is related to the desire to reduce the potential for idiosyncratic toxicities in humans, these efforts can also aid in the interpretation of the preclinical safety... 

Overall, we believe that efforts to minimize metabolic activation during dmg discovery can enhance the overall quality of drug candidates that are advanced into development in a number of respects and result in an increased probabihty of success. 

Kumar S, Mitra K, Kassahun K, Badlie TA. Approaches for minimizing metabolic activation of new drug candidates in drug discovery. Handb Exp Pharmacol 2010 (196) 511-544. 

D. C. Evans and T. A. Baillie, Minimizing the potential for metabolic activation as an integral part of drug design, Curr. Opin. Drug Discovery Dev. 8 (2005), 44-50. 

Kalgutkar, A. S., Soglia, J. R. Minimizing the potential for metabolic activation in drug discovery. Expert Opin. Drug Metab. Toxicol. 2005, 7,91-141. 

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