Migita reaction, Buchwald-Hartwig amination

The first account of palladium-catalyzed aryl C—N bond formation came from Migita in 1983 [6]. Their report described the coupling of aminostannanes with aryl halides and went on to become the foundation of modem C—N bond-forming methodology. However, it wasn t until the research groups of Buchwald [7] and Hartwig [8], independently, reported tin-free catalytic amination reactions that the synthetic potential of these processes became apparent. 

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