Micturition cycle

In addition to the acute neurotoxic sjmptoms caused by oxaliplatin, about 10-15% of patients develop a moderate neuropathy, particularly after cumulative intravenous doses of 700-800 mg/m. The symptoms of cumulative neuropathy include non-cold-related dysesthesia, paresthesia, superficial and deep sensory loss, and eventually sensory ataxia and functional impairment, which persists between treatment cycles. Most of these sjmptoms usually resolve a few weeks or months after oxaliplatin withdrawal. Lower cumulative doses (for example 510-765 mg/m ) and higher cumulative doses exceeding 1020 mg/m have been associated with incidences of cumulative grade 3 neurotoxicity of 3.2% and 50% respectively (8,9,76,77). In addition, higher cumulative doses, exceeding 1000 mg/m, have been associated with severe, atjrpical neurotoxic sjmptoms, such as micturition... 

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