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Microwave-assisted domino reaction

Scheme 21 Microwave-assisted domino reaction protocol for the synthesis of 2,3-di-substituted-quinazolin-4-ones... Scheme 21 Microwave-assisted domino reaction protocol for the synthesis of 2,3-di-substituted-quinazolin-4-ones...
A microwave-assisted domino reaction of two equivalents of anthranilic acid 71 and N-Boc amino acid 87 to furnish quinazolinobenzodiazepinones 88 was elaborated [127] (Scheme 52). The development of the domino process was possible because the homo-coupling of anthranilic acid was presumably slower than the desired reaction between acids 71 and 87. The use of microwave dielectric heating was beneficial as the formation of the seven-membered benzodiazepine ring required a higher temperature (230 °C) and a longer reaction time (20 min) compared to the six-membered analogues 79... [Pg.90]

See other pages where Microwave-assisted domino reaction is mentioned: [Pg.578]    [Pg.579]    [Pg.580]    [Pg.581]    [Pg.583]    [Pg.196]    [Pg.21]    [Pg.21]    [Pg.578]    [Pg.579]    [Pg.580]    [Pg.581]    [Pg.583]    [Pg.464]    [Pg.465]    [Pg.467]    [Pg.471]    [Pg.473]    [Pg.475]    [Pg.477]    [Pg.479]   


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Assisted reactions

Domino reactions

Microwave assisted reactions

Microwave-assisted

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