Microwave-assisted combinatorial synthesis

Westman, J., Lundin, R., Stalberg, J., Ostbye, M., Franzen, A. andHurynowicz, A., Alkylaminopropenonesand alkylamino-propenoates as efficient and versatile synthons in microwave-assisted combinatorial synthesis, Comb. Chem. High TJtroughput Screen., 2002, 5, 565-570. 

Li M, Zuo Z, Wen L et al (2008) Microwave-assisted combinatorial synthesis of hexa-substituted 1,4-dihydropyridines scaffolds using one-pot two-step multi-component reaction followed by a S-alkylation. J Comb Chem 10 436-441... 

Tu S, Li C, Li G et al (2007) Microwave-assisted combinatorial synthesis of polysubstituent imidazo[l, 2-a]quinoline, pyrimido[l, 2-a]quinoline and quinolino[l, 2-a]quinazoline derivatives. J Comb Chem 9 1144-1148... 

Hao W-J, Jiang B, Tu S-J et al (2009) Microwave-assisted combinatorial synthesis of new 3-pyrimidin-5-ylpropanamides via a solvent-dependent chemoselective reaction. J Comb Chem 11 310-314... 

Single mode microwave-assisted combinatorial synthesis of biologically interesting quinoxalinones has been described by Tung and Sun [106]. It enabled chiral libraries of quinoxalinones to be assembled by use of SNAr reactions, reduction, and concomitant cyclization under the action of microwave irradiation. 

Microwave-assisted Combinatorial Synthesis on Solid Phases [12]... 

Advances in microwave-assisted combinatorial synthesis 06CJ01500. 

Kappe CO, Stadler A (2002) Microwave-assisted combinatorial chemistry. In Loupy A (ed) Microwaves in organic synthesis. Whey, Weinheim... 

C. O. Kappe, A. Stadler, Microwave-Assisted Combinatorial Chemistry, in Microwaves in Organic Synthesis (Ed. A. Loupy), Wiley-VCH, Weinheim, 2002, p. 405 133 ... 

Lew, A., Krutzik, P.O., Hart, M.E. and Chamberlin, A.R., Increasing rates of reaction microwave-assisted organic synthesis for combinatorial chemistry /. Comb. Chem., 2002, 4, 95-105. 

Kappe, C.O. and Stadler, A., Microwave-assisted combinatorial chemistry In Loupy, A. (Ed.), Microwaves in Organic Synthesis, Wiley-VCH, Weinheim, 2002, pp. 405-433. 

The integration of microwave heating and fluorous technologies has generated a powerful solution to address both the reaction and separation issues in parallel and combinatorial synthesis. With the further development of multimode microwave reactors for plate reactions and F-SPE for plate-to-plate separations, microwave-assisted fluorous synthesis will play an even more important role in compound library synthesis. 

Cotterill 1C, Usyatinsky AY, Arnold JM et al (1998) Microwave assisted combinatorial chemistry synthesis of substituted pyridines. Tetrahedron Lett 39 1117-1120... 

Microwave-assisted Combinatorial and High-throughput Synthesis... 

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