Microspheres somatotropins

Proteins may be stabilized by encapsulation in polyanhydride microspheres. Stability of proteins with respect to water-induced aggregation has been demonstrated to be a function of polymer hydrophobicity for insulin and bovine somatotropin as model proteins (Ron et al., 1993). Encapsulation and enzymatic activity of a variety of other proteins encapsulated in P(SA FAD) was studied by Tabata et al. (1993). 

The incorporation of a variety of proteins into polyanhydride microspheres has been examined, including insulin (Mathiowitz et al, 1985 Mathiowitz and Langer, 1987), bovine somatotropin (Ron et al, 1989), chondrogenic stimulating proteins (Lucas et al, 1990), and several enzymes (Chasin et al, 1990). These matrices have been extensively characterized in vitro and efforts for in vivo characterization continue (Chasin et al., 1990). 

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