Microsomes multiplication, mode

Lim et al. [93] investigated the use of LTQ-Orbitrap to identify human liver microsomal metabolites of carvedilol, using parent mass list triggered data-dependent multiple stage accurate mass analysis. In this study, LTQ-Orbitrap was used for accurate mass measurements at a resolving power of 60,000 to obtain mass accuracy <2 ppm for all full-scan and MS" spectra in the external calibration mode. The chemical formulas obtained from high-resolution accurate mass measurements were used to confirm structures of the product ions proposed by Mass Frontier. 

---