Microcrystalline cellulose oxidized form

By using this technique acrylamide, acrylonitrile, and methyl acrylate were grafted onto cellulose [20]. In this case, oxidative depolymerization of cellulose also occurs and could yield short-lived intermediates [21]. They [21] reported an electron spin resonance spectroscopy study of the affects of different parameters on the rates of formation and decay of free radicals in microcrystalline cellulose and in purified fibrous cotton cellulose. From the results they obtained, they suggested that ceric ions form a chelate with the cellulose molecule, possibly, through the C2 and C3 hydroxyls of the anhy-droglucose unit. Transfer of electrons from the cellulose molecule to Ce(IV) would follow, leading to its reduction... 

Microcrystalline cellulose is the most compressible of any direct compression excipient. Producing a tablet of a given hardness requires less compression force for other materials. Therefore, it is usually mixed with another filler to achieve ideal compactibility and flowability of a direct compression formulation. Large particle size grades of microcrystalline cellulose are made by spray-dried processes to form dry and porous particle surfaces. The porous surfaces provide adsorption sites needed for fine dmg particles in low-dose formulations. However, microcrystalline cellulose contains trace amounts of peroxides that may lead to chemical incompatibility with oxidatively sensitive dmg substances.34... 

In this work for the first time have been studied modifieation peculiarities of microcrystalline eellulose (MCC) and its oxidized form (dialdehyde cellulose DAC) guanidine-containing monomers and polymers of vinyl and diallyl series [1-3]. The structure and some characteristics of used guanidine-containing modifiers are shown in Table 6.1. 

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