MicroChannel and Flow Technique Strategies

As with any technique in chemistry there are always limitations. Some disadvantages include  

FIGURE 11.18 Synthesis tree for McQuade (2007) plan for (5)-pregabalin hydrochloride. 

The reaction solvent to limiting reagent mass ratio for each step is as follows  

Step 1 (19.4 1), step 2 (7.5 1), and step 3 (0 1). In the third step, water is a reagent, so it is not formally counted as a solvent. This plan ranks 15th out of 24 in terms of E-total as shown by the data in Table 11.3. 

TABLE 11.3 f-Factor Breakdowns for Synthesis Plans for (S)-Pregabalin Total Mass of 

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