Microbiology continued General

Administer caspofungin by slow intravenous (IV) infusion over approximately 1 hour. Candidemia and other Candida infections Administer a single 70 mg loading dose on day 1, followed by 50 mg/day thereafter. The patient s clinical and microbiological response should dictate duration of treatment. In general, continue antifungal therapy for at least 14 days after the last positive culture. 

ABC Pharmaceutical Industries routinely monitors the microbial content of the air, inanimate surfaces, personnel, water systems, and product component bioburden. Microbiological monitoring of these areas generally reflects on the efficiency of cleaning and sanitization procedures and employee practices. Continuous environmental monitoring provides the assurance that product is produced by a controlled process that will maximize the sterility and quality of the manufactured sterile product. 

CM] A. Cunningham and P. Mass (1978), Time lag and nutrient storage effects in the transient growth response of Chlamydomonas reinhardii in nitrogen limited batch and continuous culture, Journal of General Microbiology 104 227-31. 

Figure 8. T. A2 grown under alternate limitation of acetate and thiosulfate in continuous cuiture at a diiution rate of 0.05 h . Thiosulfate (40 mM) or acetate (10 mM) was supplied to the cuiture, each for 4 h. The dashed lines indicate the minimum activities needed for uninterrupted growth. Reproduced, with permission, from Ref. 9. Copyright 1981, Society for General Microbiology.

Herbert, D., Elsworth, R. Telling, R. C. (1956). The continuous culture of bacteria a theoretical and experimental study. Journal of General Microbiology, 14, 601-22. 

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