Tobramycin Miconazole

Extracted cefamandole, cefazolin, cefoxitin, cephapirin, chloramphenicol Simultaneous acetaminophen, N-acetylprocainamide, cefaclor, cephalexin, cephalothin, ci-metidine, miconazole, moxalactam, procainamide, sulfamethoxazole, theophylline, tobramycin, vancomycin... 

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

A report describes a reduction in serum tobramycin levels, which was attributed to the use of miconazole. 

Hatfield SM, Crane LR, Duman K, Karanes C, Kiel RJ. Miconazole-induced alteration in tobramycin pharmacokinetics. ClinPharm (1986) 5, 415-19. 

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