Michael trisubstituted tetrahydrothiophenes

In addition to the chemistry described previously, a variety of enantioselective thia-Michael reactions have been developed [5]. An example of one of these approaches involved the addition of allyhc thiols to highly activated ketones using a thiourea organocatalyst (Scheme 5.5) [6]. This thia-Michael addition was carried out in a cascade process with another Michael addition to generate trisubstituted tetrahydrothiophenes under mild conditions. The reaction was highly enantioselective and high yielding. In related work. 

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