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Michael-aldol reaction, -prolinol derivatives

The domino Michael/aldol reaction of 3-halogeno-l,2-diones (273) (X = Cl, F) to a,fi-unsaturated aldehydes RCH=CHCH=0 (R = aryl, heteroaryl), catalysed by the prolinol derivatives (256), has been developed as a method for the construction of cyclopen- tanones (274) with four contiguous stereogenic centres (<94% ee, >20 1 dr)P ... [Pg.442]

A BINAP-derived bifunctional thiophosphoramide gives >98% del>99% ee in Michael addition of cyclohexanones to both aryl- and alkyl-substituted nitroolefins. Imidazolylmethyl ketones undergo one-pot Michael-aldol cascade reactions with Q ,/3-unsaturated aldehydes in DCM at 20 °C using the simple organocatalyst, prolinol... [Pg.34]

See other pages where Michael-aldol reaction, -prolinol derivatives is mentioned: [Pg.283]    [Pg.288]    [Pg.175]    [Pg.237]    [Pg.60]    [Pg.407]    [Pg.991]   
See also in sourсe #XX -- [ Pg.376 ]



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Aldol reactions derivatives

Michael-aldol reaction

Michael-aldol reaction, -prolinol

Prolinol

Prolinol reaction

Prolinols

Prolinols derivatives

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