Michael adthdon

An elegant synthesis of (5f(, 65, 8/f -6-( C(-hytltQxyethyl -2-rhytltQxymethyl penem-3-cdr-boxylic acid has been accomplished by the strategy based on the Michael adthdon and Nef reacdon CScheme 4.9)/ ... 

BalLini and coworkers have developed a new strategy for alkenyladon of carbonyl compounds based on the Michael adthdon followed by eliminadon of HNO fsee Secdon 7 3 A variety of 2-alkylidene 1,4-tholes have been conveniently prepared, in two steps, by the Michael adthdon of a nltroalkane to the appropriate enedione derivadves under basic conthdons, followed by chemoselecdve reducdon v/ith LLAlHl CEq 4 123 ... 

An intramoleculdf raLliciil cyclizdDon gives ihe exa-cyclic compounds, which has been extensively used in the synthesis of cychc compounds Michael adthdons of allyl idcohols or propargyliilcohols to nitroalkenes and the subsequent treatment v/ilhdn rathciils provide a useful method for the preparadon of sitbsdrtited ftirans fEqs 7 83 and 7 84 ... 

Another Michael adthdon route for synthesis of the pyrroLmdine alkakiide trachelan-thamidinis shown in Scheme 10.18. 

Asymmetric Michael adthdon of nitroraethane to a ctotonyl camphorsidtam gives access to the enando-pnre 2-oxoesters, which may be converted into the 3-hydroxy-5-raethylpiperidin-2-onefEq. 10.771. ... 

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