Meyer camosic acid synthesis

The first total synthesis of camosic acid (89). was accomplished by Meyer et al. [28], Meyer developed two different routes for the synthesis of camosic acid. This is exhibited in Figs. (12) and (13). 

Meyer also developed another route for the synthesis of camosic acid (89) and this is described in Fig. (13). 

The synthesis of camosic acid dimethyl ether by Meyer et al records some interesting aspects. Michael addition of ketoaldehyde with two new reagents proved very useful in the synthesis of tricyclic ketone. In the second approach a very easy method has been described for the introduction of hydroxyl group at C-l 1 position. 

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