Mevalonate-5-pyrophosphate

Mevalonate pyrophosphate, role in cholesterol synthesis, 5 142 Mevalonic acid, 2 93 14 132 alkaloid precursor, 2 78 Mexican Molango ore, 15 544 Mexican oregano, 23 169 Mexico... 

This enzyme [EC 4.1.1.33], also known as mevalonate pyrophosphate decarboxylase, catalyzes the reaction of ATP with (i )-5-diphosphomevalonate to produce ADP, orthophosphate, carbon dioxide, and isopentenyl diphosphate. 

Shama Bhat, C. Ramasarma, T. Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. Biochem. J., 181, 143-151 (1979)... 

Mevalonate kinase and mevalonate pyrophosphate decarboxylase activities of skin fibroblasts respond in parallel to altered serum lipoprotein levels [211]. 

Not all investigators are convinced that peroxisomes are involved in cholesterol biosynthesis. In contrast to Olivier and Krisans [4], Hogenboom and colleagues have found no deficiency in cholesterol biosynthesis in fibroblasts from patients with a peroxisomal biogenesis disorder (S. Hogenboom, 2003). In addition, using a variety of biochemical and microscopic techniques, they found that mevalonate kinase, phospho-mevalonate kinase, and mevalonate pyrophosphate decarboxylase are cytosolic, not peroxisomal enzymes (S. Hogenboom, 2004). 

The last step in the biosynthesis of isopentenyl pyrophosphate is the decarboxylation and dehydration of mevalonic pyrophosphate catalyzed by the enzyme mevalonic pyrophosphate anhydrodecarboxylase (E.C. 4.1.1.33). The mechanism by which this reaction occurs is not certain. Lind-berg et al. (1962) proposed a two-step reaction sequence involving phos-... 

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