Metoprolol sustained-release tablets

If the wet granulation technology is applied spray-dried PVAc/Povidone should be put in the extragranular phase to avoid the wetting of this polymer mixture. Such application is shown in in Table 106 in a formulation of metoprolol sustained-release tablets. 

Sustained release tablets for metoprolol tartrate have been prepared using xanthan gum and tragacanth (38). 

J. Varshosaz, N. Tavakoli, and S.A. Eram, Use of natural gums and cellulose derivatives in production of sustained release metoprolol tablets, DrugDeliv., 13 (2), 113-119,2006. 

---