Phenprocoumon Metoprolol

Also analyzed acebutolol, acetaminophen, alprazolam, amphetamine, atenolol, betaxolol, brotizolam, caffeine, camazepam, captopril, chloroquine, clobazam, clomipramine, cloth-iapine, clotiazepam, cloxazolam, cocaine, codeine, diclofenac, dihydralazine, dihydrocodeine, dihydroergotamine, diphenhydramine, domperidone, doxepin, droperidol, ergota-mine, ethyl loflazepate, fenethylline, fluoxetine, flupentixol, flurazepam, furosemide, gliclazide, hydrochlorothiazide, hydroxyzine, ibuprofen, imipramine, ketazolam, loprazo-1am, lorazepam, lormetazepam, maprotUine, medazepam, mepyramine, methadone, methaqualone, methyldopa, methylphenidate, metoclopramide, metoprolol, mexiletine, mianserin, midazolam, minoxidil, morphine, nadolol, nitrazepam, oxprenolol, papaverine, pentazocine, phenprocoumon, phenylbutazone, pipamperone, piritramide, practolol, pra-zepam, prazosin, promazine, promethazine, propoxyphene, propranolol, prothipendyl, quinine, sotalol, sulpride, thioridazine, trazodone, triazolam, trimipramine, tripelennamine, lyramine, verapeunil, yohimbine... 

In healthy subjects, a single dose of atenolol 100 mg or metoprolol 100 mg did not affect the AUC of a single dose of phenprocoumon, although phenprocoumon levels were slightly higher at 4 and 6 hours after the metoprolol dose. Nevertheless, neither beta blocker altered the prothrombin time response. ... 

Spahn H, Kirch W, Mutschler E, Ohnhaus EE, Kitteringham NR, Logering HJ, Paar D. Pharmacokinetic and phaimacod3niamic interactions between phenprocoumon and atenolol or metoprolol. BrJ Clin Pharmacol (19S4) 17, 97S-102S. 

---