Metoclopramide Narcotics

The effects of metoclopramide are antagonized by concurrent administration of anticholinergics or narcotic analgesics. Metoclopramide may decrease the absorption of digoxin and cimetidine and increase absorption of acetaminophen, tetracyclines, and levodopa Metoclopramide may alter die body s insulin requirements. 

NSAIDs are contraindicated after 37 weeks gestation. For refractory migraines, narcotics may be used. Salicylates and indomethacin should be avoided throughout pregnancy if possible. The use of sumatriptan is controversial. Nausea of migraines may be treated with metoclopramide. 

Drugs that may affect mexiletine include aluminum-magnesium hydroxide, atropine, narcotics, cimetidine, fluvoxamine, hydantoins, metoclopramide, propafenone, rifampin, urinary acidifiers, and urinary alkalinizers. 

Drugs that may affect metoclopramide include levodopa, anticholinergics, and narcotic analgesics. Drugs that may be affected by metoclopramide include alcohol, cimetidine, cyclosporine, digoxin, levodopa, MAO inhibitors, and succinylcholine. 

Metoclopramide Anticholinergic drugs such as atropine, benzhexol, propantheline, narcotic analgesics Antagonism - they have opposing effects on gastrointestinal activity. 

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