Gynecomastia metoclopramide

Domperidone minimally crosses the BBB it acts in the CTZ which lies outside of the BBB. As such, domperidone is less likely to cause the centrally-mediated adverse effects seen with metoclopramide and has an estimated overall incidence of 5% to 10%.1,30 However, domperidone has been associated with prolonged QT intervals, cardiac arrhythmias, and sudden death.31 It should not be used for patients with underlying long QT interval or for those on other medications that prolong the QT interval. Both metoclopramide and domperidone can cause hyperprolactinemia, galactorrhea, and gynecomastia. 

Hyperprolactinemia and galactorrhea, sometimes with gynecomastia, are classic complications of metoclopramide that can equally well occur in adults, children, or neonates (SEDA-22, 390 716). 

Madani S, Tolia V. Gynecomastia with metoclopramide use in pediatric patients. J Clin Gastroenterol 1997 24(2) 79-81. 

Endocrine Metoclopramide can cause gynecomastia, and has been reported to do so in a neonate. 

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