Gastroesophageal reflux metoclopramide

Symptomatic gastroesophageal reflux 10 to 15 mg orally up to 4 times daily 30 minutes before each meal and at bedtime. If symptoms occur only intermittently or at specific times of the day, single doses up to 20 mg prior to the provoking situation may be preferred rather than continuous treatment. Occasionally, patients who are more sensitive to the therapeutic or adverse effects of metoclopramide (eg, elderly) will require only 5 mg/dose. Guide therapy directed at esophageal lesions by endoscopy. Therapy longer than 12 weeks has not been evaluated and cannot be recommended. 

Children Infants and children (21 days to 3.3 years of age) with symptomatic gastroesophageal reflux have been treated with metoclopramide at a dosage of 0.5 mg/kg/day symptoms improved, the duration of the disease was shortened, and surgery was avoided. 

Metoclopramide (Reglan) is used in gastroesophageal reflux, diabetic gastric stasis, and as an antiemetic. Reglan is identical to older... 

Metoclopramide, a dopamine antagonisf increases LES pressure in a dose-related manner, and accelerates gastric emptying in gastroesophageal reflux patients. Unhke cisapride, however, metoclopramide does not improve esophageal clearance. Metoclopramide... 

Oral metoclopramide is indicated in the treatment of diabetic gastroparesis (10 mg 30 minutes before each meal and at bedtime for 2 to 8 weeks) and symptomatic gastroesophageal reflux (10 to 15 mg orally up to 4 times daily 30 minutes before each meal and at bedtime for 4 to 12 weeks). Furthermore, parenteral metoclopramide is indicated in prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, for prophylaxis of postoperative nausea and vomiting when nasogastric suction is undesirable, and as a single dose to facilitate small-bowel intubation when the tube does not pass the pylorus with conventional maneuvers. 

An 86-year-old man with a history of hypertension, hypothyroidism, and gastroesophageal reflux developed symptoms of cardiac failure while taking Usinopril, levothyroxine, and metoclopramide 10 mg qds [10 ]. Furosemide administration was associated with renal impairment, and followed by QT interval prolongation, which evolved into torsade de pointes. After successful defibrillation, the QT interval prolongation persisted and resolved only after metoclopramide withdrawal. 

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